Hypersensitivities The Princess and the Pea Syndrome

Published: 14th May 2008
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Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity is a state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign agent; allergy is a synonym for hypersensitivity. anaphylaxis is a form of hypersensitivity. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The causes of the hypersensitive are protein component, water which contains the chemicals and bacteria, unaware exposure to avery toxic chemical.



The Gell and Coombs classification (below) distinguishes four types of hypersensitivity reactions based on antibody (I-III) or cell-mediated (IV) reactions and constitutes a logical framework for understanding hypersensitivity reactions although. Hypersensitivity to flying insects such as flies and mosquitos is the most common cause of itching in horses. Itching is caused by the bite itself because flies have chewing mouthparts and the bite is painful for the horse. However, it's not only the bite as many horses are hypersensitive to the saliva of the insect and this increases the inflammation.



There are several types hypersensitivity and they are antibody-dependent, immune complex, cell-mediated, the immediate in which this have guinea pig is injected intravenously with an antigen. For this example, bovine serum albumin (BSA, a protein) will be used. After two weeks, the same antigen will be reinjected into the same animal.



Within a few minutes, the animal begins to suffocate and dies by a process called anaphylactic shock, stimulatory which have binding to cell surface components, the antibodies recognize and bind to the cell surface receptors, which either prevents the intended ligand binding with the receptor or mimics the effects of the ligand, thus impairing cell signaling and the delayed hypersensitivity (DH), delayed-type hypersensitivity (DTH) that which takes 24 to 72 hours to develop and is mediated by T lymphocytes rather than by antibodies; usually used to denote the subset of type IV hypersensitivity involving cytokine release and macrophage activation, as opposed to direct cytolysis, but sometimes used more broadly, even as a synonym of type IV h.



Only someone as refined and delicate as a princess would be able to feel a single pea through 23 mattresses. This strange statement is evolved from the fairy that the measurement of a true princess was one who was sensitive enough to feel a pea under a tall stack of mattresses.



The immune system is an integral part of human protection against disease, but the normally protective immune mechanisms can sometimes cause detrimental reactions in the host. Such reactions are known as hypersensitivity reactions, and the study of these is termed immunopathology. Hypersensitivity is a state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign substance. Hypersensitivity reactions are classified as immediate or delayed, types I and IV, respectively, in the Gell and Coombs classification of immune responses.



Hypersensitivity can also be a symptom of ADD and ADHD (Symptoms of Adult ADD) and may also be associated with certain mood disorders such as schizophrenia, OCD, anxiety disorders, bipolar disorder and as part of the cycle whenever someone experiences panic attacks. If you are experiencing hypersensitivity to the extent that is a health threat, see the appropriate mental health professional.







Sander Bel writes articles for depression treatments. He also writes for home remedies and anxiety depression.

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